Abstract A 39-year-old male without any preceding medical ailment presented with 12 day history of fever followed by behavioral changes with left sided weakness.He was found to AEG HKB75540NB 75CM FLAMELIGHT 5 BURNER GAS ON AUTOMATIC IGNITION GLASS HOB have Herpes Simplex Virus-1 encephalitis (polymerase chain reaction positive) and with Magnetic Resonance Imaging finding of asymmetrical frontotemporoparietal (right side affected more than left side) involvement with patchy enhancement with atypical nodular enhancement and subtle diffusion restriction.Nodular enhancement is rare in acute DC Power inflammations and is reported mainly with chronic granulomatous infections.